POS1388-HPR RELATIONSHIP BETWEEN CENTRAL SENSITIZATION AND PSYCHOLOGICAL FACTORS IN RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL, MULTICENTER STUDY

Background Affective distress (clinically significant depression, anxiety and stress) central sensitization (CS) are consistently associated with the reported sensitivity severity of pain, physical disability, poor treatment outcomes, inflammatory disease activity, potentially early mortality in rheumatoid arthritis (RA). Objectives We aimed to explore affective patients RA determine how they connected CS. Methods Used CSI measure CS Depression, Anxiety Stress Scale - 21 Items (DASS-21) evaluate negative emotional states stress. The total score ranges from 0 100, a 40 or greater has been established indicate Each three DASS-21 scales contains 7 items, divided into subscales similar content. Multiple regression analysis was used find out which factors were most likely be linked Results Overall we included 192 (age ranging 22 86 years) mean duration 5.95 (SD 13.75) years. ≥ 70/192 (36.5%). In our cohort, 32.3 (SD29.8). (Mean=10.68 SD=8.92 moderate range (10-14), whereas Depression (Mean = 10.11 SD 11.66) 15.8 SD=12.05) scores mild (10-13 15-18, respectively). 70 > 40, (Mean=12.20 SD=10.01) 14.01 13.83) 19.51 SD=12.77) all (10-14, 14-20 19-25, Conclusion symptoms common patients. Screening recognition such psychosocial disorders may help achieve optimal control good outcome. Overall, findings have implications for health policy emphasize significance identifying high-risk fibromyalgia (FM) by monitoring as an indicator severe disease. References [1]Bottesi G, Ghisi M, Altoè Conforti E, Melli Sica C. Italian version Scales-21: Factor structure psychometric properties on community clinical samples. Compr Psychiatry. 2015 Jul;60:170-81. [2]Ruhaila AR, Chong HC. Self-reported stress among Rheumatoid Arthritis Malaysian rheumatology centre prevalence correlates. Med J Malaysia. 2018 Aug;73(4):226-232. [3]Bacconnier L, Rincheval N, Flipo RM, Goupille P, Daures JP, Boulenger Combe B. Psychological over time arthritis: results longitudinal study cohort. Rheumatology (Oxford). Mar;54(3):520-7. Acknowledgements: NIL. Disclosure Interests None Declared.